Coffee is often considered a cause of diuresis and laxative effects. Diuretic effects are caused by an increase in the number of feces and an increase in the amount of water content in the stool. The main components of arabica coffee (Coffea arabica) are caffeine, a white crystalline purine, and a methylxanthine alkaloid that triggers these effects. The gastrocolic response is provoked by stimulating receptors on the stomach and small intestinal epithelial cells. This leads to increased secretion of gastrin and exorphine which can increase colonic motility. To test this hypothesis, an experiment was conducted to determine the effect of coffee on the laxative effect and urine mass in mice (Mus musculus). Mice were divided into three experimental groups: the control group treated with water (untreated), the treatment group treated with water along with 8 mg/kg caffeine extract from Arabica coffee berries (taken from pure coffee beans), and lastly the active control group treated with caffeine extract from coffee beans by drinking only water at night for 4 consecutive days.
The second group was treated with 25% (w / w) of coffee, and the third group was treated with 12.5% (w / w) of coffee. The administration was carried out using an oral gavage method. The hypothesis in this study is that increasing the coffee concentration will increase urine mass and fecal mass. Results showed that there was no significant correlation between increasing the coffee concentration and urine mass or fecal mass.
Reference: Abdullah Kafa Bihi..., Effects of Arabica Coffee (Coffea arabica) on Laxative Effect and
Urine Mass of Mice (Mus musculus), 2017 Animal Anatomy and Physiology Project Small Research Report
By Nikhil mane
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