Based on research by the University of Basel there is a decrease in glucose metabolism caused by obesity. Insulin production decrease leads to obesity.
If we have an improper intake of food it may lead to diabetes. But based on this research by Dr. Daniel Zeman-Meier of the university's Department of Biomedicine, if insulin production is reduced as in type 2 diabetes, it may contribute to hunger and be followed by obesity.
They focused on protease PC1/3 which helps in converting inactive to active forms of hormones. Therefore, deficiency of this enzyme contributes to severe endocrine disorders followed by uncontrolled hunger and obesity.
Further studies say that by turning off the same enzyme PC1/3 in mice's brains, there was no significant change in weight.
The research explained that insulin is activated by PC1/3 and further more insulin regulates the metabolism of fat and blood glucose level. Therefore, shutting off the PC1/3 insulin-producing beta cells of the pancreas in mice leads to the consumption of more calories which increases hunger and causes obesity.
It has been proved that in prediabetic patients there was a decrease in PC1/3 production.
Conclusion:
The presence of sufficient PC1/3 promotes a healthy body weight.
Reference:
Daniel T. Meier et al, Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing, Nature Communications (2022). DOI:10.1038/s41467-022-32509-4
Journal information: Nature Communications
By Priyanka Goswami
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