There are few excipients and API whose administration is difficult because of poor absorption or poor breakdown. Hence Drug delivery system came into existence where it releases activities in a controlled manner for a prolonged period of time.
The most commonly used drug delivery systems are based on polylactide-co-glycolide (PLGA) and polylactide (PLA) but they have some demerits as they degrade in the body making the environment acidic which results in the irregular release of substances and lead to local inflammation and the drug may become inactive before it is released, explains Professor Karsten Mäder from the Institute of Pharmacy at MLU. His team has been working for many years on improving existing drug systems and developing new alternatives.
Based on research, starch is a possible excipient that can be used as an alternative to PLGA and PLA. This system worked well with poorly soluble drugs when the researchers used special pharmaceutical-grade starch to make rod-shaped extrusions made by the extrusion process.
Hence, starch is a suitable carrier substance for the controlled release of drugs explains Professor Karsten Mäder from the Institute of Pharmacy at MLU.
More information:
Golbarg Esfahani et al, A starch-based implant as a controlled drug release system: Non-invasive in vivo characterization using multispectral fluorescence imaging, Journal of Controlled Release (2023).
Journal information: Journal of Controlled Release +
By Priyanka Goswami
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